Abstract
The aim of this study was to use near-infrared time-resolved spectroscopy (TRS) to determine the absolute values of cerebral blood volume (CBV) and cerebral hemoglobin oxygen saturation (ScO2) during the immediate transition period in term neonates and the changes in optical properties such as the differential pathlength factor (DPF) and reduced scattering coefficient (μs’). CBV and ScO2 were measured using TRS during the first 15 min after birth by vaginal delivery in term neonates who did not need resuscitation. Within 2–3 min after birth, CBV showed various changes such as increases or decreases, followed by a gradual decrease until 15 min and then stability (mean (SD) mL/100 g brain: 2 min, 3.09 (0.74); 3 min, 3.01 (0.77); 5 min, 2.69 (0.77); 10 min, 2.40 (0.61), 15 min, 2.08 (0.47)). ScO2 showed a gradual increase, then kept increasing or became a stable reading. The DPF and μs’ values (mean (SD) at 762, 800, and 836 nm) were stable during the first 15 min after birth (DPF: 4.47 (0.38), 4.41 (0.32), and 4.06 (0.28)/cm; μs’: 6.54 (0.67), 5.82 (0.84), and 5.43 (0.95)/cm). Accordingly, we proved that TRS can stably measure cerebral hemodynamics, despite the dramatic physiological changes occurring at this time in the labor room.
Highlights
Evaluation of the immediate postnatal cerebral oxygen metabolism and hemodynamics is essential for understanding extrauterine adaptation
One of the seven neonates was born via forceps delivery but the others were born via a normal vaginal delivery
Two neonates were excluded from the analysis because the μs ’ was abnormal according to previous work [10]
Summary
Evaluation of the immediate postnatal cerebral oxygen metabolism and hemodynamics is essential for understanding extrauterine adaptation. Sci. 2019, 9, 2172 immediately after birth are explosive and can induce fetal distress and asphyxia. The physiological processes after birth remain unclear and include cerebral vasodilation, vasoconstriction, and oxygenation. Because the brain is the most sensitive organ system of the infant, it is important to assess its autoregulation after birth
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