Abstract

A relatively simple, reproducible method for the measurement of serum IgE has been described. It is practical and could be performed inmost laboratories and the results obtained in a few days. A known reference serum, standard (such as the WHO standard) could be employed, and IgE myeloma protein would not be needed. The IgE values in serum may possibly be of diagnostic value in differentiating atopic dermatitis from other dermatoses and atapic versus nonatopic rhinitis and asthma. The studies presented confirm the work of previous investigators as to elevated IgE serum levels in atopic eczema, parasitic infestations, and, to a lesser degree, respiratory allergies. The additional (coincidental?) findings of increased serum IgE levels in patients with chronic infection, eosinophilia, and trichinosis need further elaboration.

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