Abstract
Non-thermal atmospheric pressure plasma jet could generate various kinds of radicals on biosolution surfaces as well as inside the biosolutions. The electron temperature and ion density for this non-thermal plasma jet have been measured to be about 0.8~1.0 eV and 1 × 1013 cm−3 in this experiment, respectively, by atmospheric pressure collisional radiative model and ion collector current. In this context, the hydroxyl OH radical density inside the biosolutions has been also investigated experimentally by ultraviolet absorption spectroscopy when the Ar non-thermal plasma jet has been bombarded onto them. It is found that the emission and absorption profiles for the other reactive oxygen species such as NO (226 nm) and O2*− (245 nm) are shown to be very small inside the biosolution in comparison with those for the OH radical species. It is found that the densities of OH radical species inside the biosolutions are higher than those on the surface in this experiment. The densities of the OH radical species inside the deionized water, Dulbecco’s modified eagle medium, and phosphate buffered saline are measured to be about 2.1 × 1016, 1.1 × 1016, and 1.0 × 1016 cm−3, respectively, at 2 mm downstream from the surface under optimized Ar gas flow of 200 sccm. It is also found that the critical hydroxyl OH radical density for the lung cancer H460 cells to experience an apoptosis is observed to be around 0.3 × 1016 cm−3 under 1 min plasma exposure in this experiment.
Highlights
For elimination of the limitations for vacuum plasma operation with least amount of energy and cost, so-called non-thermal atmospheric pressure plasma jet (hereafter non-thermalPlasma Chem Plasma Process (2014) 34:457–472 plasma) has been emerged recently
For Ar gas flow rates ranged from 100 to 350 sccm, the electron temperature and plasma ion density of non-thermal plasma jet have been measured by optical emission spectroscopy based on the atmospheric pressure collisional radiative (CR) model [12] and by the electrical ion current signals at the grounded collector electrode passing through the mA, W, with current duration of which is obtained from a1boRuTt T0
A simple CR model has been employed in this experiment to determine the electron temperature of non-thermal plasma jet operating at atmospheric pressure by using the relative emission intensities of only four 2p Ar lines
Summary
Plasma Chem Plasma Process (2014) 34:457–472 plasma) has been emerged recently. This kind of non-thermal plasma has been attracted to areas of biotechnology with their diversity of forms for easy use. A lot of various reactive chemical species could be generated by non-thermal plasma jet. Non-thermal plasmas jets with diverse types have recently been developed and used in emerging novel biomedical applications. The first practical studies on plasma-based treatment of chronic wounds or tumor treatment with non-thermal plasma jet has been very promising [1,2,3,4]. For achievements of the technical requirements for medical instrumentation, advanced non-thermal plasma sources must have some electron temperature and requires specified radical species
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