Measurement of Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT), Fibrinogen Level, D-Dimer in Sudanese Infants and Children with Sepsis Khartoum State, 2022

Abstract

Background: Sepsis is the most common worldwide cause of death in infants and children. It was Known that coagulative and inflammatory parameters were involved in the host’s defense against sepsis resulted from severe infection and inflammation. Materials and Methods: This was cross sectional study conducted at Albraa pediatric center, Khartoum, Sudan during the period from May 2022 to August 2022, to measure PT, APTT, fibrinogen level, D- dimer in Sudanese infants and children with sepsis. 50 patients were selected as a case group, and apparently healthy donors with no history of any coagulation problems or any chronic disease were selected as control group. 2.8 ml of venous blood samples were collected in Tri Sodium Citrate anticoagulant. The coagulation tests (PT, APTT, fibrinogen) were performed using semiautomatic device (coagulometer). I chroma was used for the D- dimer. Results When compared between case and control there was highly significant difference (p.value 0.000), in PT, APTT, fibrinogen and D- dimer. In addition, there was insignificant difference when the PT, APTT fibrinogen and D- dimer in cases compared with the gender, CRP and bacterial culture, and there was negative correlation between the parameters and the age except the D-dimer had appositive correlation. The most common types of isolated bacteria in sepsis patients is staphylococcus aureus. Conclusion: This study concluded that, PT, APTT, fibrinogen and D- dimer was significantly increased in patients with sepsis.