Abstract
BackgroundHigh mobility group box 1 (HMGB1), intensively studied in adult patients by several investigators, is suggested to cause potentially fatal conditions such as systemic inflammatory response syndrome (SIRS) and disseminated intravascular coagulation (DIC). However, little is known about the role of this protein in neonates. MethodsIn total, 173 full-term neonates were divided into 4 groups according to mode of delivery: scheduled cesarean section (group E, n=67), unscheduled cesarean section (group ER, n=10), normal delivery (group N, n=64) and other modes of vaginal delivery (group CN, n=32). HMGB1 concentration in umbilical cord blood and plasma samples collected 5days after birth were compared among these 4 groups. We also attempted to determine a reference value for HMGB1 concentrations in neonates. ResultsThe HMGB1 reference value in neonates was 2.0–35.3ng/ml in groups E and N (n=131). The concentration was significantly higher in group ER than in group E (P=0.00022), and was also higher in group CN than in group N (P=0.00721). ConclusionsTo our knowledge, this study is the first to determine a reference value for HMGB1 concentrations in neonates. We also revealed significantly elevated HMGB1 concentrations in association with ischemic reperfusion injury caused by certain delivery modes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
