Measurement of oral health quality of life among patients who underwent haematopoietic stem-cell transplantation.

Nayara Fernanda Pereira,Cíntia Yuki Fukuoka,Maria Gabriela Haye Biazevic,Alyne Simões Gonçalves,Edgard Michel-Crosato,Garles Miller Matias Vieira,Fábio Abreu Alves,Paula Verona Ragusa Da Silva

doi:10.1590/1807-3107bor-2018.vol32.0078

Nayara Fernanda Pereira, Cíntia Yuki Fukuoka + Show 6 more

Open Access

https://doi.org/10.1590/1807-3107bor-2018.vol32.0078

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Abstract

Oral mucositis is a painful condition that occurs in patients who have undergone haematopoietic stem-cell transplantation (HSCT) and has a huge impact on their quality of life. The objective of this study was to examine the extent to which interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α) are associated with oral health quality of life among patients who underwent HSCT. A. C. Camargo Cancer Center patients were evaluated over 20 months at 4 different time-points: a) at patient admission (M1); b) on the day of infusion of HSC (M2); c) 12 and 20 days after the first day of the conditioning regimen for autologous and allogeneic transplantation, respectively (M3); and d) 30 days after the first day of the conditioning regimen (M4). Mucositis clinical evaluations were performed using World Health Organization (WHO) criteria. Oral health quality of life was measured using the Oral Health Impact Profile short form (OHIP-14), Oral Mucositis Quality of Life (OMQoL) and Patient-Reported Oral Mucositis Symptom (PROMS) scales. Correlations between clinical data and quality of life scores were examined. STATA 11.0 was used to perform the statistical analyses (5% level of significance). Eighty-two patients participated in the study; 62.2% were male, 28.05% had multiple myeloma, and the mean age was 48.49 years (SD 13.76). Higher scores (worse quality of life) were observed as mucositis scores increased, but the results were not significant. The OMQoL had a high correlation with OHIP-14 (0.8377), but the correlation between the PROMS scale and the OHIP-14 was lower (0.6643). Higher concentrations of IL-6 and TNF-α were associated with worse quality of life, according to all indices (p < 0.05). Oral mucositis was associated with quality of life scores (p < 0.01).

Highlights

Most patients who have undergone haematopoietic stem-cell transplantation (HSCT) are diagnosed with lymphomas and leukaemia
High blood levels have been associated with worse prognosis and survival rates among patients diagnosed with non-Hodgkin’s lymphoma.[4]
HSCT patients who were 18 years of age or older were included in the study, and patients who refused to participate after being invited and those with no medical conditions indicated on the questionnaires were excluded from the study

Summary

Introduction

Most patients who have undergone haematopoietic stem-cell transplantation (HSCT) are diagnosed with lymphomas and leukaemia. In 2012, 566,000 new cases of lymphomas with 305,000 deaths and 352,000 new cases of leukaemia with 265,000 deaths occurred worldwide.[1]. Oral mucositis is a painful condition that can affect patients who have undergone HSCT and has an impact on their quality of life.[2] The pathogenesis of the condition presents several challenges that can interfere. High blood levels have been associated with worse prognosis and survival rates among patients diagnosed with non-Hodgkin’s lymphoma.[4] Quality of life might be affected by these conditions, since worse clinical conditions will impact the patient’s quality of life, such as through their ability to eat, to swallow or to interact to other persons socially

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