Abstract
In this study, a measurements of neutron field using a special positioning device with a <sup>6</sup>Li + Si detector and image plate is described. The measurements were provided for Boron Neutron Capture Therapy (BNCT) channel of the LVR-15 reactor in the Research Centre Rez Ltd., Czech Republic. Mapping of neutron field represents an essential and crucial part of planning BNCT treatment (especially for patients suffering from brain tumor Glioblastoma Multiforme).
Highlights
Glioblastoma multiforme [1,2,3,4] is the most common malignant radio-resistant and chemoresistant tumor of the central nervous system which has been incurable for decades and even today, the prognosis is not favorable [5]
Boron Neutron Capture Therapy (BNCT) is unique selective radiotherapy based on capture of non-radioactive nuclide 10B by cancer cells and the subsequent capture of thermal neutrons resulting in the nuclear reaction 10B(n, α)7Li
An absolutely essential part of the treatment planning is determination of parameters and proper setting of correct compensation of neutron beam. The purpose of this project was to measure the spatial distribution of neutrons inside the epithermal horizontal channel of the research reactor LVR-15 [6], which is used for the method of Boron Neutron Capture Therapy
Summary
Glioblastoma multiforme [1,2,3,4] is the most common malignant radio-resistant and chemoresistant tumor of the central nervous system which has been incurable for decades and even today, the prognosis is not favorable [5]. Despite the advanced diagnostics (especially in neuroimaging), and various multimodal therapies that include surgical resection followed by radiation therapy (and alternatively chemotherapy) still remains a considerable problem with finding efficient and gentle treatment of the sensitive area of brain tissue In this regard, Boron Neutron Capture Therapy (BNCT) is unique selective radiotherapy based on capture of non-radioactive nuclide 10B by cancer cells and the subsequent capture of thermal neutrons resulting in the nuclear reaction 10B(n, α)7Li. In this regard, Boron Neutron Capture Therapy (BNCT) is unique selective radiotherapy based on capture of non-radioactive nuclide 10B by cancer cells and the subsequent capture of thermal neutrons resulting in the nuclear reaction 10B(n, α)7Li These products of reaction selectively damage cancer cells while healthy tissue is spared of radiation load. The purpose of this project was to measure the spatial distribution of neutrons inside the epithermal horizontal channel of the research reactor LVR-15 (the Research Centre Rez Ltd., Czech Republic) [6], which is used for the method of Boron Neutron Capture Therapy
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