Abstract

Background The CPT induces endothelial-dependent vasodilation with increased myocardial blood flow (MBF) in normal coronary arteries. It has been used to demonstrate abnormal coronary vasomotion by invasive (angiography) and non-invasive techniques (SPECT and PET). Cardiovascular Magnetic Resonance (CMR) allows the assessment of MBF in separate myocardial layers due to its high spatial resolution, but has not previously been used to measure physiological responses to CPT.

Highlights

  • The Cold Pressor Test (CPT) induces endothelial-dependent vasodilation with increased myocardial blood flow (MBF) in normal coronary arteries

  • Each perfusion scan was separated by 15 minutes

  • Endocardial MBF was significantly higher than epicardial MBF at rest (p

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Summary

Background

The CPT induces endothelial-dependent vasodilation with increased myocardial blood flow (MBF) in normal coronary arteries. It has been used to demonstrate abnormal coronary vasomotion by invasive (angiography) and non-invasive techniques (SPECT and PET). Cardiovascular Magnetic Resonance (CMR) allows the assessment of MBF in separate myocardial layers due to its high spatial resolution, but has not previously been used to measure physiological responses to CPT

Methods
Results
Discussion

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