Measurement of Methytetrahydrofolate Level among Sudanese Women with Hypertensive Disorders of Pregnancy, Khartoum state 2023

Abstract

Hypertensive disorders are a common complication of pregnancy that put women and their fetuses at disproportionate risk for further complications, as well as a life-long sequela. This study aimed to measure the Methytetrahydrofolate Level (folate) among Sudanese women with hypertensive disorders of pregnancy. This were a case-control hospital-based study conducted at the laboratory of the Omdurman maternity hospital – in Khartoum, Sudan during the period of January 2023 to March 2023. It included All patients attending Omdurman maternity hospital that diagnosed with hypertensive disorders of pregnancy, and apparently healthy women were included as a control group. ELIZA (mindary 8000) was used for folate level measurement. The mean of folate levels in the cases was (12.9± 3.7), and in the control group was (33.9±2.5), when compared the folate mean between the case and control group there was a highly significant decrease with (p. v= 0.001). While the folate level had insignificant differences with the history of hypertension and types of hypertensive pregnancy (p. v > 0.05). Also has appositive correlation with the age (p. v<0.05). In the Sudanese women with hypertensive pregnancy the folate level was significantly decreased when compared between the case and control group, and had insignificant differences with the history of hypertension, and types of hypertensive pregnancy and had a positive correlation with the age.