Abstract
BackgroundRetinal ganglion cell (RGC) death is a common cause of loss of vision during glaucoma. Pattern electroretinogram (PERG) is an objective measure of the central retinal function that correlates with macular GCL thickness. The aim of this study is to determine possible relationships between the N95 amplitude of pattern electroretinogram (PERGamp) and macular ganglion cell/inner plexiform layer thickness (GCIPLT).Methods and findingsThis was a retrospective and comparative study including 74 glaucoma patients (44 early stage and 30 advanced stage cases) and 66 normal control subjects. Macular GCIPLT was measured using Cirrus spectral domain-optical coherence tomography. Standard automated perimetry and pattern ERGs were used in all patient examinations. Three types of regression analysis (broken stick, linear regression, and quadratic regression) were used to evaluate possible relationships between PERGamp and GCIPLT. Correlations between visual field parameters and GCIPLT were evaluated according to glaucoma severity. The best fit model for the relationship between PERGamp and GCIPLT was the linear regression model (r2 = 0.22; P < 0.001). The best-fit model for the relationship between visual field parameters and GCIPLT was the broken stick model. During early glaucoma, macular GCIPLT was positively correlated with PERGamp, but not with visual field loss. In advanced glaucoma, macular GCIPLT was positively correlated with both PERGamp and visual field loss.ConclusionsPERGamp was significantly correlated with macular GCIPT in early glaucoma patients, while visual field performance showed no correlation with GCIPLT. PERGamp can therefore assist clinicians in making an early decision regarding the most suitable treatment plan, especially when GCIPLT is thinning with no change in visual field performance.
Highlights
The main characteristic of glaucoma is loss of retinal ganglion cell axons, which typically leads to optic neuropathy
PERGamp was significantly correlated with macular GCIPT in early glaucoma patients, while visual field performance showed no correlation with ganglion cell/inner plexiform layer thickness (GCIPLT)
Clinicians in making an early decision regarding the most suitable treatment plan, especially when GCIPLT is thinning with no change in visual field performance
Summary
The main characteristic of glaucoma is loss of retinal ganglion cell axons, which typically leads to optic neuropathy. Retinal ganglion cell (RGC) death is a common cause of loss of vision during glaucoma and most optic neuropathies. Stress in the cellular and molecular environment that exceeds the survival capacity of RGCs can lead to progressive damage to ganglion cells and their fibers. This damage can induce retinal dysfunction, as revealed by flash electroretinogram (FERG) or pattern electroretinogram (PERG) recordings [1,2,3,4]. The aim of this study is to determine possible relationships between the N95 amplitude of pattern electroretinogram (PERGamp) and macular ganglion cell/inner plexiform layer thickness (GCIPLT)
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