Abstract
The intracellular free ([Ca 2+] i) of the bullfrog sympathetic ganglion cell was measured with fura-2 fluorescence under various conditions, and compared with changes in membrane potential recorded with an intracellular electrode. The [Ca 2+] i was 109 nM on average under the resting condition and increased by raising the extracellular K +, stimulating repetitively the pre- or post-ganglionic nerve, or by applying acetylcholine or muscarine. Since all these procedures depolarized the cell membrane, most of the rise in [Ca 2+] i could be the result of opening of voltage-dependent Ca 2+ channels. However, Ca 2+ entries through nicotinic acetylcholine receptor channels and the channel activated by the muscarinic acetylcholine receptor were also indicated by considering the threshold for the opening of voltage-dependent Ca 2+ channels (for both entries) or a limited number of the cells showing the latter response.
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