Measurement of Helicobacter Pylori in Patients with Bronchial Asthma

Abstract

Background: Current evidence indicates an inverse association between Helicobacter pylori and asthma and allergy. H. pylori is a Gram-negative bacterium which represents the major cause of peptic ulcer and gastric cancer, and preferentially elicits a T helper (Th)-1 response. Many H. pylori factors, such as the neutrophil-activating factor of H. pylori (HP-NAP), are able to drive Th-1 polarization and to display a powerful inhibition of allergic Th-2 response. Special attention has been drawn to HP-NAP as a potential novel strategy for the prevention and treatment of asthma and atopy. Aim of the Work: This study was aimed to measure helicobacter pylori in patient with bronchial asthma. Subjects and Methods: This study included a total of 50 patients with bronchial asthma and 20 age-matched control individuals attending at AL-Hussein, Al-Azhar University Hospitals in the period between April 2018 and December 2018. All patients underwent full history taking, complete clinical examination, plain chest X-ray, routine lab investigations, spirometry before and after bronchodilators and H. pylori antigen in stool by ELISA. Results: The results of this study revealed that there is a relation between bronchial asthma and helicobacter pylori. Conclusion: There were improvement in pulmonary function tests in asthmatic patients with H. pylori positive more than asthmatic patients with H. pylori negative.