Abstract
Gastric acid secretion in the anaesthetized rat has been measured by continuously recording the conductivity of the effluent in the reperfusion system previously developed by the authors. (H +) and (Na +) were measured by titration and flame photometry respectively and compared with the total conductivity of the effluent. The differences between the calculated and measured conductance were within the experimental error of the observations. There was no clear relationship between rates of secretion of hydrogen ions and sodium ions in this preparation. Conductance was used to measure acid concentration and to assay inhibitors and stimulants of gastric acid secretion. A conductivity meter has been designed and used to measure gastric acid secretion in the perfused rat stomach preparation. Measurements of conductivity were shown to be a measure of the hydrogen ion concentration of the effluent. The quality and linearity of the response was superior to that achieved with pH methods. The sensitivity of the system has been increased which has enabled 10 ng of gastrin I to give a significant effect. It was possible to monitor six preparations with one meter during assays of urogastrone and gastrin.
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