Abstract
Concentration changes of haemoglobin and cytochromes indicative of tissue perfusion and oxygenation can be quantitatively evaluated from near-infrared (NIR) measurements of absorption and optical pathlength through tissue. The accuracy of such measurements is limited as current bedside instrumentation cannot measure optical pathlength. Using a recently developed phase-resolved spectroscopic technique we can produce continuous and simultaneous measurements of changes in both attenuation and optical pathlength at four wavelengths in the NIR in a bedside instrument. The change in optical pathlength through arm muscle during a cuff occlusion is compared with the absolute pathlength estimated from time resolved spectroscopy measurements in the laboratory. These show that the pathlength varies by 4–10% during the occlusion, demonstrating the need for continuous measurements of optical pathlength.
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