Abstract
A major limitation of near-infrared spectroscopy (NIRS) is its high sensitivity to the scalp and low sensitivity to the brain of adult humans. In the present work we used multi-distance hyperspectral NIRS (hNIRS) to investigate the optimal source-detector distances, wavelength ranges, and analysis techniques to separate cerebral responses to 30 s breath-holds (BHs) from the responses in the superficial tissue layer in healthy adult humans. We observed significant responses to BHs in the scalp hemodynamics. Cerebral responses to BHs were detected in the cytochrome C oxidase redox (rCCO) at 4 cm without using data from the short-distance channel. Using the data from the 1 cm channel in the two-layer regression algorithm showed that cerebral hemodynamic and rCCO responses also occurred at 3 cm. We found that the waveband 700–900 nm was optimal for the detection of cerebral responses to BHs in adults.
Highlights
Near-infrared spectroscopy (NIRS) was proposed for human brain measurements in 1970s [1]
High sensitivity to the scalp and low sensitivity to the brain of adult humans remains a main problem of NIRS in spite of numerous attempts to resolve it using different continuous-wave [5], time-domain [6], and frequency-domain approaches [7]
In the present work we approached the above aspects of cerebral NIRS using multi-distance hyperspectral NIRS
Summary
Near-infrared spectroscopy (NIRS) was proposed for human brain measurements in 1970s [1] It has been considered for clinical monitoring of cerebral status during various medical conditions in adults, such as cardiac surgeries, cardiac arrest, and traumatic brain injury [2]. In such conditions significant circulatory and metabolic changes occur in the entire body, including the scalp, where NIRS sensitivity is maximal [3,4]. In the present work we approached the above aspects of cerebral NIRS using multi-distance hyperspectral NIRS (hNIRS)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
