Abstract
Enzyme-linked immunosorbent assays (ELISA) have been developed for the measurement of β 2-microglobulin (B2M), retinol-binding protein (RBP), α 1-microglobulin (A1M) and urine protein 1 (UP1) in children. Results from random urine samples in 43 children (31 for B2M) are, when corrected for urine creatinine (geometric mean (range)): B2M 9.8 (6.0–40.7) μg/mmol, RBP 8.1 (< 1–24.5) μg/mmol, A1M 0.4 (0.1–2.2) mg/mmol and UP1 17.8 (< 2–309.4) μg/mmol. Fractional excretions (FE) in 23 children (14 for B2M) are (geometric mean (range)): FEB2M 0.04% (0.02–0.10%) and FEUP1 0.10% (0.01–1.21%). Results in overnight urine collections are also presented. Our results extend existing data for normal ranges in adults to include children and provide data on UP1 concentrations.
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