Abstract
Low water solubility is the major problem in the formulation and development of new chemical compounds as well as their generic development. The solubility of anti-cancer drug, Erlotinib hydrochloride, in supercritical carbon dioxide was investigated for the first time at various temperatures and pressures (308-338 K and 12-30 MPa). Based on the results, the solubility of Erlotinib HCL varied in the range of 1.20 × 10−6-2.12 × 10−5 g/l. The correlation of solubility data was studied with Peng-Robinson's equation of state and four density-based semi-empirical models including Chrastil, Bartle et al., Méndez-Santiago, Teja, Kumar-Johnston, and modified Wilson model. The accuracy of models was also explored based on statistical criteria, including average absolute relative deviation (AARD %) and adjusted correlation coefficient (Radj). The modified Wilson model exhibited superior correlation with empirical solubility data in supercritical carbon dioxide (AARD=10.45 %, Radj=0.9876).
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