Abstract
The solubility of paracetamol in water−isopropanol mixtures at 30 °C using the regular-solution theory, the UNIFAC model, and the UNIQUAC model is predicted and compared with the corresponding experimental values reported in part A of this study. The results of the ideal solubility show that Δcp should be integrated with respect to differential molar heat capacity changes with temperature, if sub-cooled liquid heat capacity is approximated by liquid heat capacity. The modified regular-solution theory underestimates the solubility, whereas the UNIFAC model overestimates it. The UNIQUAC model results in the best predictions. However, various vapor−liquid equilibrium data sets to calculate the UNIQUAC solvent−solvent adjustable parameters result in different accuracies.
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