Abstract
Separation processes are widely used in chemical and biotechnical processes. Especially biomagnetic separation is an important issue among effective separation processes to separate the magnetic micron and submicron particles. It is necessary to establish and determine a high magnetic field or field gradient in the separation cell. However, it is not easy to determine the magnetic field gradient in the working region for different separation in practice. The reason for these difficulties is that the magnetic cells used in biochemical separation have different geometries and there are no simple and useful systems to easily measure these magnetic fields. Two main objectives are aimed in this study. First, a simple measuring device design can measure gradient magnetic fields with high precision of about 0,01mm and, secondly, obtain simple empirical expressions for the magnetic field. A magnetometer with Hall probes that works with the 3D printer principle was designed and tested to measure the magnetic field. Magnetic field changes were measured according to the surface coordinates on the measurement platform or measuring cell. Numerous experimental measurements of gradient magnetic fields generated by permanent magnets have been taken. The results obtained from the studies and results from the proposed empirical models were compared.
Highlights
Many and different kinds of mixtures, ranging in size from nanometers to several hundreds of micrometers, are used in chemical and biotechnological processes
Unlike HGMS, magnetic bioseparation or MDT have the following specific characteristics: Gradient magnetic fields are mainly generated by permanent magnets
It is necessary to know the changes of the magnetic field intensity BB and gradient ∇BB in the target region of the magnetic field for each separation process
Summary
Many and different kinds of mixtures, ranging in size from nanometers to several hundreds of micrometers, are used in chemical and biotechnological processes. Magnetic force at these levels may be insufficient for the separation of bioparticles with weak magnetic properties In this case, it is possible to increase the strength of the magnetic system by increasing the magnetic field gradient through the creation of new structures. The formulas obtained by methods based on the calculation of the scalar magnetic field potential, commonly used in classical electromagnetic field theory, are complicated and not appropriate for the practical calculations in separation practice [9], [11], [17], [32] This prevents both the progression of biomagnetic separation theory and the expansion of its applicability in different areas. The measurement results were demonstrated with tables and graphics, and necessary comparisons, and recommendations have been presented
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