Abstract
Solubilities of cinildipine in supercritical carbon dioxide was measured at T = (313, 323, and 333) K over the pressure range (12.0 to 36.0) MPa by a flow type apparatus. The solubility behavior of the solid shows an analogous trend with a crossover region of the isotherms in 15.0-18.0 MPa. The experimental solubility data are well correlated with semi-empirical density-based models including the Chrastil, Bartle, and MST models with the absolute average relative deviation (AARD) from (7.0 to 7.5)%, and the solubility data satisfy the self-consistency test according to the MST model.
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