Abstract
In this paper the chronic disease of diabetes is examined within a control context, with treatment actions constituting external control actions that replace the control failures that the disease processes represent. Consideration is given to the strategic control problem of insulin therapy adjustment. It is shown that the combination of good measurement practice and the adoption of time series methods as applied to appropriate structural models can provide powerful insights into the dynamic features of glucose metabolism. This in turn can form the basis of a linear modelling approach to provide advice on the strategic insulin dosage adjustment problem for the diabetic patient.
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