Measurement and Analysis of Tissue Temperature During Microwave Liver Ablation

Abstract

We measured tissue temperature changes during ex vivo microwave ablation (MWA) procedures for bovine liver tissue. Tissue temperature increased rapidly at the beginning of the MW power application. It came to a plateau at 100 degrees C to 104 degrees C before it increased again. We split the changes of tissue temperature versus time into four phases. This suggests that tissue temperature changes may be directly related to tissue water related phenomena during MWA, including evaporation, diffusion, condensation and tissue water composition. An additional analysis indicated the lesion boundary at approximately 50 degres C to 60 degrees C temperature. We also measured the water content of ablated tissue lesions and examined the relationship of tissue water content and tissue temperature by mapping temperature to remaining tissue water after ablation. The results demonstrate significant tissue water content changes and lead to a better understanding of tissue water movement.