Abstract
Measles Outbreak in Africa—Is There a Link to the HIV-1 Epidemic?
Highlights
Acquired maternal antibodies protect infants against measles until the time of measles vaccination, which in most developing countries is administered at 9 months of age
Since the control of measles and HIV-1 relay on efficient CD8 T cell responses, the increased morbidity observed in children with HIV-1 upon measles infection can be related to the shift in cytokine profile from Th1 to Th2 occurring in these young individuals and impairing T cell responses to both pathogens [8]
A Th1 to Th2 shift during the course of chronic HIV-1 infection is associated with progression to AIDS [9], and measles virus infection suppresses the ability of T cells to produce IL-12, hampering T cell responses [10]
Summary
Acquired maternal antibodies protect infants against measles until the time of measles vaccination, which in most developing countries is administered at 9 months of age. In 1992, an increased risk of measles before 9 months of age was reported in children born to mothers with HIV-1 [4], which was suggested to be due to lower levels of passively acquired antibodies at birth [5].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
