Abstract
The serum antibody titres of measles in patients with subacute sclerosing panencephalitis (S.S.P.E.) were considerably higher than those of matched controls. The measles titres among siblings of S.S.P.E. patients were in the same range as those of the siblings of the controls. This finding is compatible with the concept that the host response to the measles infection preceding S.S.P.E., rather than an immunogenetic deficiency in the family, is the important factor. The finding of normal titres to measles in the siblings of S.S.P.E patients raises further questions about the significance of the observations of raised measles antibody titres in the siblings of multiple-sclerosis patients.
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