Abstract
Objective. We aimed to investigate the mean platelet volume (MPV) of the patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods. The medical records of 46 patients with the diagnosis of NAION and 90 control subjects were retrospectively evaluated. All participants underwent complete ocular examination including intraocular pressure (IOP) measurement. Hematocrit, MPV, hemoglobin, and platelet levels of the patients with NAION were compared with those of control subjects. Results. There was no significant difference between the groups in platelet counts (p = 0.76). NAION group had significantly higher MPV values (8.25 ± 1.26 fL) than that of control subjects (7.64 ± 1.01 fL) (p < 0.001). Multivariate logistic regression analysis showed that MPV is an independent predictor of NAION (odds ratio = 1.61; 95% confidence interval (CI) = 1.13–2.28; p = 0.007). The mean IOP was significantly higher in NAION group (p < 0.001). IOP was also found as an independent predictor of NAION according to the regression analysis (OR = 1.27; 95% CI = 1.08–1.48; p = 0.003). Conclusion. Our results demonstrated that the MPV values were significantly higher in NAION patients, suggesting that larger platelets may contribute to the pathogenesis of the NAION.
Highlights
Anterior ischemic optic neuropathy (AION) is a condition with unilateral, painless, and sudden visual loss caused by acute ischemic damage of the anterior region of the optic nerve in elderly patients
It has been reported that glucose-6-phosphate dehydrogenase (G6PDH) deficiency has a protective effect against the development of nonarteritic anterior ischemic optic neuropathy (NAION) and retinal vein occlusion (RVO) [11, 12]
Patients with NAION were consecutively recruited at the Dicle University, School of Medicine, Department of Ophthalmology
Summary
Anterior ischemic optic neuropathy (AION) is a condition with unilateral, painless, and sudden visual loss caused by acute ischemic damage of the anterior region of the optic nerve in elderly patients. There are two types of AION: arteritic (AAION) and nonarteritic (NAION) [1,2,3]. Thrombophilia, increased fibrinogen or cholesterol levels, and von Willebrand factor antigen have been shown to be of significant importance in the development of NAION [2, 10]. It has been reported that glucose-6-phosphate dehydrogenase (G6PDH) deficiency has a protective effect against the development of NAION and retinal vein occlusion (RVO) [11, 12]. Pinna et al [12] explained this protection with the reduced ability of esterification and accumulation of cholesterol in the arteries G6PDH deficient subjects
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