Abstract
Thyroid cancer is the most prevalent endocrine cancer and is evident in nearly 5% of thyroid nodules. The correlation between mean platelet volume (MPV) and many other cancer types has been investigated previously. However, the correlation between papillary thyroid carcinoma (PTC) and MPV has not yet been studied in detail. The aim of this study was to examine whether MPV would be a useful inflammatory marker to differentiate PTC patients from cases of benign goiter and healthy controls. Preoperative MPV levels in patients with PTC were found to be significantly higher when compared with benign goiter patients and healthy controls ((respectively, 8.05 femtoliter (fl), 7.57 fl, 7.36 fl, p=0.001). After surgical treatment of PTC patients, a significant decrease in MPV levels was seen (8.05 fl versus 7.60 fl, p=0.005). ROC analysis suggested 7.81 as the cut-off value for MPV (AUC=0.729, sensitivity 60%, specificity 80%). In conclusion, maybe changes in MPV levels can be used as an easily available biomarker for monitoring the risk of PTC in patients with thyroid nodules, enabling early diagnosis of PTC.
Highlights
Thyroid cancer is the most prevalent endocrine cancer and is seen in nearly 5% of thyroid nodules (Pacini et al, 2006)
Mean platelet volume (MPV) is a marker associated with functional changes in platelets, which can be detected with routinely used hemocytometers (Gasparyan et al, 2006; Wang et al, 2011)
This study demonstrated that papillary thyroid carcinomas (PTCs) patients had significantly higher MPV values when compared with benign goiter patients and healthy controls
Summary
Thyroid cancer is the most prevalent endocrine cancer and is seen in nearly 5% of thyroid nodules (Pacini et al, 2006). Thyroid cancer incidence has rapidly increased during the past few decades, and the increase is nearly exclusively due to increases in the incidence of papillary thyroid carcinomas (PTCs), with no significant change for the other histotypes (Cramer et al, 2011; Pellegriti et al, 2013). With their secretions of proinflammatory factors, chemokines, and growth factors, platelets play an important role in cancer diseases with an inflammatory background (George, 2000). MPV indicates mean platelet size and reflects platelet production rate and stimulation (Threatte, 1993). Larger platelets are more metabolically and enzymatically active than smaller platelets (Mangalpally et al, 2010)
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