Abstract
Mean platelet volume (MPV) is affected by inflammation in many conditions, such as in inflammatory bowel diseases, rheumatoid arthritis, and ankylosing spondylitis. Conflicting reports exist about its value in stable and exacerbating chronic obstructive pulmonary disease (COPD). The aim of the present study was to find out whether there was a significant change in the MPV during acute exacerbation of COPD compared with smokers and healthy controls. The study was carried out on 135 adult patients of both sexes (77 men and 58 women), who presented to Alexandria Main University Hospital. Patients were categorized into three groups of 45 patients each; patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) made up group I, healthy smokers without COPD made up group II, and healthy controls made up group III. MPV values were 8.34 ± 0.95 and 9.28 ± 0.67 fl in patients with acute exacerbation of COPD and in smokers, respectively. MPV values in the control group were 9.12 ± 0.60 fl. MPV values were significantly lower in patients of acute exacerbation than in smokers and controls (both, P < 0.001). A positive correlation was found between MPV and measured forced expiratory volume at first second (FEV1), C-reactive protein, and total leukocytic count in total sample. MPV was found to be decreased in acute exacerbations of COPD compared with smokers and healthy controls. Evaluation of MPV in COPD exacerbation may indicate systemic inflammation. Thus, MPV may be used as a negative acute-phase reactant in COPD exacerbation.
Highlights
Chronic obstructive pulmonary disease (COPD), a common preventable and treatable disease [1], is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases [2]
Patients were categorized into three groups of 45 patients each; patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) made up group I, healthy smokers without COPD made up group II, and healthy controls made up group III
Mean platelet volume (MPV) values were significantly lower in patients of acute exacerbation than in smokers and controls
Summary
Chronic obstructive pulmonary disease (COPD), a common preventable and treatable disease [1], is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases [2]. Inhaled cigarette smoke and other noxious particles cause lung inflammation, which results in the induction of parenchymal tissue destruction and disruption of normal repair and defense mechanisms and fibrosis of small airways. These pathological changes lead to air trapping and progressive airflow limitation, in turn to breathlessness and other characteristic symptoms of COPD [1,2]. Conflicting reports exist about its value in stable and exacerbating chronic obstructive pulmonary disease (COPD)
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