Mean platelet volume as a prognostic factor in neonatal respiratory distress

Abstract

ObjectiveTo evaluate mean platelet volume (MPV) as a prognostic factor in neonatal respiratory distress.BackgroundRespiratory distress syndrome (RDS) is a major cause of morbidity and mortality in preterm infants. MPV is an indicator of platelet function. It may be considered a risk factor for the development of RDS.Patients and methodsThis was a case–control study conducted on 50 (21 males and 29 females) Egyptian preterm neonates. Of them, 25 were previously diagnosed as having RDS, as a patient group, and 25 were apparently healthy age-matched and sex-matched neonates as a control group. All of them were subjected to full history and physical examination. Blood samples were taken on first and third day. Blood for complete blood count was obtained by either venipuncture, arterial puncture, or through a central catheter. complete blood count included MPV, platelet count, and white blood cell count.ResultsMPV on the first day (fl) in the study group [10.8 (9.1, 11.2)] was significantly higher than controls [7.9 (7.6, 8.2)], with P value less than 0.001. MPV on third day (fl) in study group [11.5 (10.4, 12.2)] was significantly higher than controls [8.3 (8.1, 8.5)], with P value less than 0.001. However, platelet count on third day (×109/μl) in the study group [146 (103, 170)] was significantly lower than in controls [176 (150, 202)], with P = 0.032.ConclusionMPV is a simple and readily available biomarker, and it is indicated that platelet may have been involved in the physiopathologic process of RDS.