Mean platelet volume and abnormal left ventricle geometric patterns in patients with untreated essential hypertension

Abstract

Abnormal left ventricle (LV) geometric patterns are associated with a greater risk of hypertensive vascular complications. The mean platelet volume (MPV) reflects the platelet activity, and is associated with overall vascular mortality. Although association between MPV and LV hypertrophy in hypertensive patients has been investigated, relation between abnormal LV geometric patterns and MPV was not studied so far. The aim of this study is to investigate the relationship between MPV and abnormal LV geometric patterns in hypertensive patients. Measurements were obtained from 223 patients with untreated essential hypertension (Mean age = 52.1 ± 5.2 years). Four different geometric patterns (NG; normal geometry, CR; concentric remodelling, EH; eccentric hypertrophy, CH; concentric hypertrophy) were determined according to the LV mass index (LVMI) and relative wall thickness (RWth). MPV, high sensitive C-reactive protein (hsCRP) and other biochemical markers were measured in all patients. The highest MPV values were determined in CH group compared with NG, CR and EH groups (p < 0.05, for all). MPV values were similar among the NG, CR and EH groups (p > 0.05, for all). MPV was associated with age, glucose, hsCRP, RWth, LVMI and LV geometry in bivariate analysis (p < 0.05, for all). Age (β = 0.110, p = 0.033), LVMI (β = 0.471, p < 0.001) and hsCRP (β = 0.525, p < 0.001) were independent predictors of high MPV in multiple linear regression analysis. The highest MPV values were observed in the CH group. This result may be associated with increased inflammation and LV hypertrophy in this geometric pattern.