Mean, lowest, and highest pulsatility index of the uterine artery and adverse pregnancy outcome in twin pregnancies

Abstract

We read with great interest the article published by Klein et al1 on uterine artery Doppler screening for preeclampsia and adverse twin pregnancy outcome in the December issue of the Journal. The authors confirmed that the reference range for uterine artery Doppler pulsatility indices (PIs) are different in twins compared with singleton pregnancy and that there is a significant difference in PI between twin and singleton pregnancy. Finally, they demonstrated quite convincingly a significant association between increased PI and adverse pregnancy outcome, presumably as a consequence of impaired placental development.