Abstract
A number of key biological processes involving cell migration in which cells traverse boundaries separating well‐defined tissues can be modeled in terms of mean first‐passage time (MFPT) problems in confined domains. Motivated by this scenario, we consider suitable three‐dimensional domains on which MFPT functions , fulfilling a Poisson‐like equation and different boundary conditions on the surface enclosing , are studied. By extending methods coming from potential theory, the calculation of boils down to dealing with inhomogeneous linear integral equations having singular kernels on . The latter are solved compactly and yield consistent 's for several domains and homogeneous boundary conditions. Moreover, the integral equation approach allows us to analyze the MFPT with mixed (Dirichlet‐Neumann) boundary conditions on for the case of a closed spherical surface with Dirichlet conditions on most of , except for a small complementary surface domain with Neumann conditions.
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