Abstract
BackgroundThe goal of this study was to investigate the impact of mean corpuscular volume (MCV) in patients with esophageal squamous cell carcinoma (ESCC) who underwent surgical resection.MethodsA total of 615 patients with ESCC who underwent esophagectomy were analyzed. Patients were divided into two groups according to the standard MCV: the high MCV group (>100 fl) and the low MCV group (≤100 fl). Survival analyses were performed to calculate overall survival (OS) and cancer-specific survival (CSS) and investigate the independent prognostic factors.ResultsFifty-one patients (8.3%) were in the high MCV group, and the other 564 patients (91.7%) were defined as the low MCV group. MCV was significantly correlated with sex, habitual alcohol or tobacco use, tumor length, body mass index, and multiple primary malignancies (P < 0.05). Elevated MCV was significantly correlated with poor survival in univariate and multivariate analyses. However, in subgroup analyses, MCV was found to be correlated with survival only in patients with alcohol or tobacco consumption and not in patients without alcohol or tobacco consumption.ConclusionsPretreatment MCV was correlated with survival in ESCC patients after esophagectomy. However, its prognostic value might only exist in patients with alcohol or tobacco consumption.
Highlights
Esophageal carcinoma is a common digestive system malignancy with high mortality [1]
We investigated the prognostic value of mean corpuscular volume (MCV) in patients with esophageal squamous cell carcinoma (ESCC) who underwent surgical resection and tried to elucidate the prognostic significance of MCV in these patients according to the history of alcohol and tobacco consumption
Of the 817 patients with esophageal carcinoma who underwent esophagectomy between September 2014 and December 2017, 761 patients were diagnosed with ESCC
Summary
Esophageal carcinoma is a common digestive system malignancy with high mortality [1]. The identification of factors associated with high risk prior to treatment is important for planning the individual therapeutic strategy for patients with malignancies. The TNM staging system is widely used for predicting the outcomes of esophageal cancer and other malignancies. A MCV in ESCC Patients separate clinical stage (cTNM) was provided in the 8th edition for ESCC to be used as a prognostic indicator before treatment, its predictive value is still limited. We think that it is necessary to develop other accessible and effective indicators to predict the outcome of esophageal cancer patients before treatment, which may help to improve individualize their treatment. The goal of this study was to investigate the impact of mean corpuscular volume (MCV) in patients with esophageal squamous cell carcinoma (ESCC) who underwent surgical resection
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