Meal-Engendered Circadian-Ensuing Activity in Rats

Abstract

Large meals scheduled at greater-than-circadian periods (such as T = 31 h) tend to elicit enhanced activity approximately 24 h subsequent to receipt. These studies characterized the process responsible for this meal-engendered “circadian ensuing activity” (meal CEA). Female Sprague–Dawley rats were housed in stations containing a running wheel, pellet dispenser, and lights. Young, middle-aged, or suprachiasmatic–nucleus (SCN)-lesioned rats were given two 1-h meals every 31 or 34 h. Meals were separated by alternating short and long fasts. Most young intact rats engaged in enhanced activity approximately 24 h subsequent to the start of the two-meal series. This circadian ensuing activity underwent large, abrupt daily displacements in response to daily meal delays, was manifested to some degree at all times of day, had an amplitude that was modulated by circadian time of day, was attenuated in middle-aged rats, was evident in SCN-lesioned rats, and oscillated following termination of the feeding schedule. A single experience with food at a novel time of day can “reset” an SCN-independent oscillating process responsible for a circadian activity pattern. CEA has features not readily accommodated by present models of “food-anticipatory activity.” The readiness with which the process can be reset implies a keen sensitivity to shifts in the time of food availability but could also produce aberrant behavioral patterns. A T >> 24-h feeding schedule appears to be an ideal procedure with which to study the specific food-related factors responsible for resetting circadian processes and producing a subsequent reallocation of daily activity.