Abstract
Methods Eighty HIV-1 infected drug naive patients who had atleast one viral load <150 copies/mL within six months of therapy and 21 healthy subjects were included. The HIV patients were categorized into viral responders (n=40) and non responders, two consecutive viral load ≥400 copies/mL after six months of ART (n=40). The genotype analysis of G2677T (GG/GT/TT in exon-21) and C3435T (CC/CT/TT in exon-26) was performed using PCR RFLP. Statistical analysis was carried out using chi-square test in SPSSver16.
Highlights
Multi drug resistance (MDR1) gene polymorphisms can alter the drug transport function of p-glycoprotein and are often associated with resistance to antiretroviral therapy (ART) in HIV-1 patients
In this study, we investigated the association of single nucleotide polymorphisms in MDR1 gene (exon-21 and exon-26) with responsiveness to ART in HIV-1 patients
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Summary
Multi drug resistance (MDR1) gene polymorphisms can alter the drug transport function of p-glycoprotein and are often associated with resistance to antiretroviral therapy (ART) in HIV-1 patients. We investigated the association of single nucleotide polymorphisms in MDR1 gene (exon-21 and exon-26) with responsiveness to ART in HIV-1 patients
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