Abstract
Stable integration of the human MDR gene into the HSC of animals has been used to study the biological properties of the totipotent stem cell. The site of proviral integration of the MDR gene provides a clonal marker that can be used to follow the progeny of transduced HSC throughout differentiation and over time. The expressed protein product, p-glycoprotein, has also been assessed in these studies. MDR gene transfer has potential therapeutic applications in cancer therapy by providing resistance to a number of commonly used chemotherapeutic agents, and as a selection for a cotransduced nonselectable gene. Promising results in the murine system indicate that the transfer and expression of the human MDR gene may prove to be valuable in human gene therapy.
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