Abstract
This study compared the expression of MDM2 and SUMO-1 proteins between actinic cheilitis and squamous cell carcinoma (SCC) of the lip. Methods: The sample consisted of lower lip mucosa specimens obtained from patients with a clinical and histopathological diagnosis of actinic cheilitis (n = 26) and SCC (n = 25) as well as specimens of semimucosa (n = 15) without clinical alterations. The tissue samples were stained with hematoxylin-eosin and anti-MDM2 and anti-SUMO-1 antibodies. Data were analyzed by Kruskal-Wallis and Dunn's tests (5%).
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