Abstract
Malignant tumour osteolysis is a frequent complication of cancers and multiple myeloma. It can cause skeletal related-events including pathological fractures, spinal cord compression, bone pain or hypercalcemia, with a significant alteration of quality of life and survival. Bisphosphonates (BP) play an important role in the management of this malignant osteolysis, via an inhibition of osteoclastmediated bone resorption, and a potential direct anti-tumour activity. Novel therapeutic targets such as specific RANKL antibodies are being investigated currently and are promising.
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