Abstract
MCPIP: a key player in macrophage polarization.
Highlights
Macrophage polarization state depends on their microenvironment that provides the cues for reversible states of activation
How the transcription factors STAT6/KLF4 induce the biological processes that are necessary for IL-4induced M2 polarization was only recently elucidated
A protein that plays a central role in this M2 polarization was identified as the first member of a novel class of zinc finger proteins induced by MCP-1 treatment of human peripheral blood monocytes with MCP-1 and named MCPIP
Summary
Macrophage polarization state depends on their microenvironment that provides the cues for reversible states of activation. TLR activation by LPS leads to NFkB activation that regulate production of inflammatory cytokines characteristic of M1 macrophages. Stimulation of IFNα receptor triggers JAKmediated tyrosine phosphorylation leading to dimerization of STAT-1 that binds to promoters of genes encoding NOS2, the MHC II transactivator and IL-12 leading to the production of the M1 markers.
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