Abstract
Novel MCO high-flux membranes for hemodialysis have been developed with optimized permeability, allowing for filtration close to that of the natural kidney. A comprehensive in vitro characterization of the membrane properties by dextran filtration is presented. The sieving profile of pristine membranes, as well as that of membranes exposed to blood for 40 minutes, are described. The effective pore size (Stokes-Einstein radius) was estimated from filtration experiments before and after blood exposure, and results were compared to hydrodynamic radii of middle and large uremic toxins and essential proteins. The results indicate that the tailored pore sizes of the MCO membranes promote removal of large toxins while ensuring the retention of albumin.
Highlights
Novel MCO high-flux membranes for hemodialysis have been developed with optimized permeability, allowing for filtration close to that of the natural kidney
Such membranes have been used in small pilot trials for controlled time periods, and the results indicate that the expanded toxin removal might benefit the patients by decreasing the general inflammatory state[3]
The sieving profile of the MCO high-flux membranes as determined by dextran filtration are representatively presented in Fig. 1, together with that of one conventional high-flux membranes and one high cut-off membrane
Summary
Novel MCO high-flux membranes for hemodialysis have been developed with optimized permeability, allowing for filtration close to that of the natural kidney. The effective pore size (Stokes-Einstein radius) was estimated from filtration experiments before and after blood exposure, and results were compared to hydrodynamic radii of middle and large uremic toxins and essential proteins. During the last decade some experience has been gathered with high permeability membranes such as the high cut-off membranes Such membranes have been used in small pilot trials for controlled time periods (up to 12 weeks), and the results indicate that the expanded toxin removal might benefit the patients by decreasing the general inflammatory state[3]. The sieving properties of the membranes before and after blood contact are reported, and the pore size during operation (i.e., hemodialysis treatment) is compared to the size of uremic toxins and vital proteins
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