Abstract
Abstract McMurry has started the application of the low‐valent titanium as reducing agent for several functional group and studied the scope of coupling of the carbonyl groups using LiAlH 4 , LiBH 4 , etc. in combination with TiCl 3 or TiCl 4 is generally known as the McMurry coupling or McMurry reaction. The combination of TiCl 3 and Zn/Cu couple in DME or TiCl 3 ‐Li in DME is known as the McMurry reagent. This reaction generally gives trans ‐olefins but sometimes contaminated with pinacol. The study finds the formation of the predominant cis ‐stilbene from acetophenone under the McMurry coupling condition is due to the π ‐π preassociation. This coupling reaction has been further modified to enhance the chemoselectivity and diastereoselectivity. This reaction is useful in the preparation of olefins.
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