Abstract
Luminescence functionalization of ordered mesoporous MCM-41 silica was realized by depositing aYVO4:Eu3+ phosphor layer on its surface via the Pechini sol–gel process. This material, which combinesthe mesoporous structure of MCM-41 and the strong red luminescence property ofYVO4:Eu3+, has been studied as a host carrier for drug delivery/release systems. The structure, morphology,texture and optical properties of the materials were well characterized by x-ray diffraction(XRD), Fourier infrared spectroscopy (FT-IR), transmission electron microscopy (TEM),N2 adsorption and photoluminescence (PL) spectra. The results indicated that the specific surfacearea and pore volume of MCM-41, which were directly correlated to the drug-loadingamount and ibuprofen (IBU) release rate, decreased in sequence after deposition ofYVO4:Eu3+ and loading of IBU as expected. The IBU-loadedYVO4:Eu3+@MCM-41 system still showed red luminescence under UV irradiation (365 nm) and acontrolled release property for IBU. In addition, the emission intensity ofEu3+ increases with an increase in the cumulative released amount of IBU, making the extent ofdrug release easily identified, tracked and monitored by the change of luminescence,which demonstrates its potential application in drug delivery/release systems.
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