MCM/ZrO2 nanoparticles modified electrode for simultaneous and selective voltammetric determination of epinephrine and acetaminophen

Abstract

A novel MCM/ZrO2 nanoparticles modified carbon paste electrode (MZ-CPE) was fabricated and used to study the electro oxidation of epinephrine (EP) and acetaminophen (AC) and their mixtures by electrochemical methods. The modified electrode showed electrocatalytic activity toward EP and AC oxidation with a decrease of the overpotential by 173 mV to a less positive potential for EP at the surface of the MZ-CPE and an increase in peak current at pH 7.0. Differential pulse voltammetry peak currents of EP and AC increased linearly with their concentrations in the ranges of 1.0 × 10−6–2.5 × 10−3 and 1.0 × 10−6–2.0 × 10−3 M, respectively, and the detection limits for EP and AC were 5.0 × 10−7 and 4.5 × 10−7 M, respectively.