Abstract
Mck1 kinase is a new player in the DNA damage checkpoint pathway.
Highlights
UCSF Helen Diller Comprehensive Cancer Center, Univerisity of Califorinia, San Francisco, California, United States of America a1111111111 a1111111111 a1111111111 a1111111111 a1111111111
While Rad53, Chk1, and their homologues target some proteins in this category, they primarily act on a large number of substrates that are not directly adjacent to sites of DNA damage, including cell cycle regulators, such as Sld3 [8, 9] and Pds1 [10]
Liu and colleagues [12] show that the highly conserved GSK3-related Mck1 kinase is a downstream target of Rad53 and functions in the Dun1-independent ribonucleotide reductase (RNR) activation pathway
Summary
UCSF Helen Diller Comprehensive Cancer Center, Univerisity of Califorinia, San Francisco, California, United States of America a1111111111 a1111111111 a1111111111 a1111111111 a1111111111. While Rad53, Chk1, and their homologues target some proteins in this category, they primarily act on a large number of substrates that are not directly adjacent to sites of DNA damage, including cell cycle regulators, such as Sld3 [8, 9] and Pds1 [10].
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