Abstract
Researchers at the Hospital for Sick Children, University of Toronto and other centers in Canada used serial clinical and MRI examinations performed over a minimum of 24 months to retrospectively evaluate the 2010 and 2005 McDonald criteria for the diagnosis of pediatric multiple sclerosis (MS).
Highlights
Researchers at the Hospital for Sick Children, University of Toronto and other centers in Canada used serial clinical and MRI examinations performed over a minimum of 24 months to retrospectively evaluate the 2010 and 2005 McDonald criteria for the diagnosis of pediatric multiple sclerosis (MS)
In a total of 2,362 3T brain MRI scans acquired from 469 subjects, each 10ng/ml higher 25-hydroxyvitamin D level was associated with a 15% lower risk of a new T2 lesion (p= 0.004), a 32% lower risk of a gadolinium-enhancing lesion (p=0.002), and lower subsequent disability (p=0.037)
Vitamin D levels are inversely associated with MS activity on brain MRI
Summary
Researchers at the Hospital for Sick Children, University of Toronto and other centers in Canada used serial clinical and MRI examinations performed over a minimum of 24 months to retrospectively evaluate the 2010 and 2005 McDonald criteria for the diagnosis of pediatric multiple sclerosis (MS). Both the 2005 and 2010 criteria demonstrated high sensitivity (100%), specificity (86%), positive predictive value (76%), and negative predictive value (100%) for children older than 11 years with non-acute disseminated encephalomyelitis (ADEM) presentations. In younger children with a non-ADEM presentation, positive predictive value of the 2010 criteria was only 55%.
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