MCA-DN: Multi-path convolution leveraged attention deep network for salvageable tissue detection in ischemic stroke from multi-parametric MRI.

Abstract

Accurate and timely treatment of ischemic stroke can restore the blood flow in the affected area and reduce the risk of disability and death. Identification and localisation of both direct and collateral blood flow restriction from MRI using computational intelligence play a crucial role in assisting manual diagnosis decisions in stroke treatment. A novel multi-path convolution leveraged attention based deep network (MCA-DN) is proposed to address this challenge. MCA-DN combines multi-path convolution derived attention making different weighted filters in each attention convolution sub-path, with interactions on the same level of abstraction. This facilitates the network to focus on voxels with enhanced weighted activations, directing to a plausible lesion. Such a proposition of acquiring attention by embedding multiple filter paths, also prioritizes the selective activation of multi-parametric MRI sequences. The multi-path convolution assisted attention block allows the network layers to gain more insights on the input tensor, enabling the expansion of hypothesis search space with a controlled parameter count. The algorithm is evaluated on 139 patients of 3 datasets with 4 sub-datasets, including 2 benchmarked challenge datasets of ISLES-2015, 2017. MCA-DN achieved parametric measures of Dice similarity coefficient: 77.3%, sensitivity: 82.8%, and specificity: 98.8%, for stroke segmentation, outperforming the five state-of-the-art methods in the field with encouraging success. Competitive performance of the MCA-DN demonstrates immense potential to assist patient-specific stroke treatment planning by estimating the benefit of reperfusion.