MC13-0030 Regulation of hepatocyte growth factor-mediated cell proliferation and apoptosis through high-motility group A1 in stomach cancer cells

Abstract

serve as a biomarker for evaluation of neoadjuvant chemotherapy (NAC) in localy advanced breast cancer. Materials and Methods: A retrospective study was performed, including 29 patients who received NAC and underwent two MRI examinations, one before (EX1) and one during NAC (EX2). The apparent diffusion coefficient (ADC) was measured at both examinations. Postoperative pathological examination was used as the golden standard for the evaluation of tumour response with a binary model: responders and non-responders according to the presence of residual vital tumour. Statistical analysis was performed using Wilcoxon rank sum test. Results: From the 29 patients 21 were non-responders (72.5%) and 8 showed complete pathological response (27.5%). There was no significant difference between responders and non-responders for EX1 (p=0.96) but a significant difference (p=0.004) was found for EX2 between the two response groups. After treatment, responders (mean ADC = 0.865) showed higher values than non-responders (mean ADC = 0.414) indicating higher cellularity in the non-responders group. Moreover, the relative difference of ADC values between the two time points was statistically different for the two response groups showing more important increase of the ADC value for the responder group. Conclusions:DWI-MRI could have a potential monitoring role in neoadjuvant treatment for locally advanced breast cancer. Responders showed higher ADC values than non-responders at EX2 and more important increase of the ADC value between EX1 and EX2.