Abstract
To the Editor.— As Drs Adornato and Engel point out, Duchenne muscular dystrophy exhibits elevated plasma MB creatine phosphokinase (CPK) levels and several investigators have documented the presence of MB CPK in skeletal muscle and in the plasma from this particular group of patients. In our study (Archives136:421-424, 1976) we were concerned with normal skeletal muscle because of the need to differentiate CPK level elevations due to muscle trauma in otherwise normal patients from elevations due to myocardial infarction. We, as others, have observed elevated levels of plasma MB CPK activity in patients with Duchenne muscular dystrophy and also in patients with polymyositis. 1 The suggested explanation to account for the MB CPK in neuromuscular disorders is in keeping with the facts known regarding CPK ontongeny. However, it is important to note that patients with Duchenne muscular dystrophy also have active necrosis of myocardium that may account for the
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
