Mayer-Type Optimal Control of Probabilistic Boolean Control Network With Uncertain Selection Probabilities.

Abstract

This article considers a Mayer-type optimal control problem of probabilistic Boolean control networks (PBCNs) with uncertainty on selection probabilities which obey Beta probabilistic distributions. The expectation with respect to both the selection probabilities and the transitions of state variables is set as a cost function, and it deduces an equivalent formulation as a multistage decision problem. Furthermore, the dynamic programming technique is applied to solve the problem and performs a novel optimization algorithm in the fashion of semitensor product. A numerical example of a biological model of apoptosis protein demonstrates the effectiveness and feasibility of the proposed framework and algorithms.