May preablative thyroglobulin level be a prognostic indicator for papillary thyroid cancer?

Elgin Ozkan,Nuriye Ozlem Kucuk,Mine Araz,Cigdem Soydal,Yasemin Genc

doi:10.15761/cmi.1000122

Abstract

May preablative thyroglobulin level be a prognostic indicator for papillary thyroid cancer?

Highlights

Well differentiated papillary carcinoma accounts for approximately 90% of thyroid cancers [1]
If the relation between preablative Tg-off and recurrence was studied in two different groups, it was found that in the low risk group there was no significant relation between the recurrence rates and increasing preablative Tg-off levels (χ2=0.241, p=0,623), but in the high risk group, it was not statistically significant, there was a trend to raise in the recurrence rates with the increasing preablative Tg-off levels (χ2=3.482, p=0,062). In this retrospective study where a large long-term followed-up papillary thyroid cancer patient group was included, it is founded that preablative Tg-off value is not a statistically important prognostic risk factor when compared to the other risk factors
In all our patients with papillary thyroid cancer, mean tumor size was calculated as 14.4±5.9 mm

Summary

Introduction

Well differentiated papillary carcinoma accounts for approximately 90% of thyroid cancers [1]. Well differentiated thyroid cancer (DTC) has a quite well prognosis with 85-93% 10 year survival rates [2]. Therapy of DTC is surgery and radioactive iodine treatment. The aim of the radioiodine therapy is the ablation of the possible residual thyroid tissue after surgery and detection of metastatic foci. After surgery and radioiodine ablation, serum thyroglobulin (Tg) levels is an important marker in the follow-up of the disease. Progressive increase in the Tg levels is an early and real marker for recurrent disease [3]. It has been reported that the Tg levels measured 6 or 12 months later than the radioiodine ablation without L-thyroxine (T4) supression (Tg-off) is an important parameter for detection of disease progression risk [4,5,6]

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Conclusion