Abstract
It is established that Growth Hormone (GH) affects gonadal function at hypothalamic, pituitary and gonadal sites, and the effect of GH/IGF-I axis on spermatogenesis is well known. IGF-I is secreted by Sertoli Cells, secondary spermatocytes, spermatids and spermatozoa, and abnormal sperm parameters seem to correlate with lower serum IGF-I serum levels. Some authors reported a beneficial effect of GH treatment in infertile men, with the increase of spermatozoa number and motility in cases of oligoasthenoteratozoospermia. On the other hand, other authors did not confirm these findings. The aim of this study was to evaluate the role of GH treatment in normogonadotropic oligoasthenozoospermic patients no responsive to gonadotropins treatment in improving semen characteristics, evaluating the role of patients IGF-I serum levels
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